Recent studies. Primary effusion lymphoma (PEL) is a rare type of large B-cell lymphoma associated with human herpesvirus 8 (HHV8) infection. To dissect CAR signaling, we designed a CAR that targets an epitope from latent membrane protein 2 A (LMP2 A) of the Epstein–Barr virus (EBV) presented on HLA*A02:01. Recent studies revealed that besides well-described myeloid-derived suppressor cells (MDSCs), tumor-associated macrophages (TAMs) or regulatory T-cells (Tregs), erythroid progenitor cells (EPCs) play an important role in the regulation of immune response and tumor progression. Cancer cells harness normal cells to facilitate tumor growth and metastasis. Having reported that HER2 expression and resistance to HER2-targeted therapies can be regulated by Junctional. Exposure to SHI time- and dose-dependently inhibited tumor cell growth and proliferation in parental and DX-resistant PCa cells, accompanied by cell cycle arrest in the G2/M or S phase and modulation of cell cycle regulating proteins. Journal Citation Reports (Clarivate Analytics, 2020) 5-Year Impact Factor: 4.596 ℹ Five-Year Impact Factor: 2019: 4.596 In vitro, miR-21 knockdown decreased survival in all BrCa subtypes in the presence of radiation. Annual Reviews Rankings in Journal Citation Reports (Clarivate Analytics) 2020 Release of Journal Citation Reports. Techniques to develop three-dimensional cell culture models are rapidly expanding to bridge the gap between conventional cell culture and animal models. Accumulation of F-18 fluorodeoxyglucose (FDG) may reflect tumour characteristics based on its metabolic activity. All Journals Nutrition and Cancer List of Issues Volume 73, Issue 3 Nutrition and Cancer. The first editor-in-chief was Fred W. Stewart, who held that position until 1961.The current editor-in-chief is Fadlo R. Khuri. This allows T cells, normally restricted by the major histocompatibility complex (MHC), to be redirected to target cells by their surface antigens, such as tumor associated antigens (TAAs). Because of this, CAR and TCR signaling can be compared directly, allowing us to study the involvement of other signaling molecules, such as coreceptors. Real-world data (RWD), that is, data from sources other than controlled clinical trials, play an increasingly important role in medical research. Importantly, TARC is also produced by malignant Hodgkin and Reed–Sternberg (HRS) cells of classical Hodgkin lymphoma (cHL). Primary effusion lymphoma (PEL) is a rare type of large B-cell lymphoma associated with human herpesvirus 8 (HHV8) infection. Here, we evaluated gene and surface expression of molecules involved in cellular chemotaxis in freshly isolated human NK cells compared with NK cells expanded ex vivo using two different feeder cells lines: Epstein-Barr virus (EBV)-transformed lymphoblastoid cell lines (LCLs) or K562 cells with membrane-bound (mb) 4-1BB ligand and interleukin (IL)-21. ... turnover is an important factor in resistance management via adaptive therapy. ANNOUNCEMENTS. Those released substances and exosomes, along with exogenous HMGB1, promoted cancer cell survival and protected cells from doxorubicin cytotoxicity. EPCs are immature erythroid cells that differentiate into oxygen-transporting red blood cells. We also discuss the recent advances and applications of tumor organoids with an emphasis on tumor modeling, drug screening, personalized medicine and immunotherapy. The significant antitumor effects induced by SHI to parental and DX-resistant PCa cells make the addition of SHI to standard therapy a promising treatment strategy for patients with advanced PCa. International Scientific Journal & Country Ranking. It plays an important role in T cell development, trafficking and activation of mature T cells after binding to its receptor C-C chemokine receptor type. Sequential administration of anti-PD-1 and anti-Tim-3 combined with an SA-GM-CSF-anchored vaccine overcomes adaptive immune resistance to reject established bladder cancer Xinji Zhang, Guang Liu, Xianghua Shi, Xiaojun Shi, Jinlong Li, Lijun Mo, Jimin Gao, Zhaolin Long, Wanlong Tan J. Mutations in human Trib isoforms (Trib1, 2, and 3) have been associated with metabolic disease and linked to leukemia and the. Cancers (ISSN 2072-6694) is an international, peer-reviewed open access journal on oncology. Ease of generation, ability for long-term culture and cryopreservation make organoids suitable for a wide range of applications. Add your e-mail address to receive forthcoming issues of this journal: The statements, opinions and data contained in the journal, © 1996-2021 MDPI (Basel, Switzerland) unless otherwise stated. ISSN: 00278874. High-mobility group box 1 (HMGB1) is a type of exosomal cargo, and the antiplatelet drugs aspirin and dipyridamole interfered with its incorporation into the exosomes. Please visit the COVID-19 & Cancer Resource Center where COVID-related content is freely available. Positron emission tomography (PET) has unique characteristics for quantitative assessment of tumour biology in vivo. Social Media Impact . Organoid and spheroid cultures have distinct and overlapping purposes and differ in cellular sources and protocol for establishment. RWD provide the only means of addressing questions about risk factors and exposures that cannot be “controlled”, or when assessing rare outcomes. Nonetheless, many challenges hinder development of this therapy, such as cytokine release syndrome (CRS) and the efficacy of CAR-T treatments for solid tumors. ISSN: 0007-9235. In conclusion, this novel 3D cell culture method involving ES-PDX-derived cells is a suitable model to study ES pathobiology and can assist in the development of novel drugs against this disease, complementing PDX studies. Cancers (ISSN 2072-6694; CODEN: CANCCT) is a peer-reviewed Open Access journal of oncology published semimonthly online by MDPI. As leiomyosarcoma patients are challenged by the development of metastatic disease, effective systemic therapies are the cornerstone of outcome. Exosome release inhibitor GW4869 exhibited suppressive effects as well. Patients with PEL usually present with an effusion, but occasionally with an extracavitary mass. Thirty-five (50%) patients presented with effusion only, 27 (39%) had an extracavitary mass or masses only, and eight (11%) had both effusion and extracavitary disease. The clinical applicability of TARC is diverse. those of the individual authors and contributors and not of the publisher and the editor(s). TARC-mediated signaling initiates a positive feedback loop that is crucial for the interaction between HRS and T cells. CAR sustained the transduced signal significantly longer, but at a lower magnitude, than did TCR. Here, we proposed a worm-based (WB) microfluidic biosensor to rapidly. The success of breast cancer therapies targeting the human epidermal growth factor receptor-2 (HER2) is limited by the development of drug resistance by mechanisms including upregulation of HER3. Of 12,298 journals, only 239 titles, or 1.9% of the journals tracked by JCR, have a 2017 impact factor of 10 or higher. Thymus and activation-regulated chemokine (TARC) is produced by different cell types and is highly expressed in the thymus. Journal of the National Cancer Institute Impact Factor 9.01, IF, number of citations, detailed analysis and journal factor. Recent work using the Drosophila model has provided important insights into novel facets of conserved Tribbles functions in stem cell quiescence, tissue regeneration, metabolism connected to insulin signaling, and tumor formation linked to the Hippo signaling pathway. We sought to determine the role of miR-21 in BrCa tumor initiation, progression and treatment response. Most notably, we observed drastic downregulation of C-X-C chemokine receptor type 4 (CXCR4) and upregulation of C-C chemokine receptor type 5 (CCR5) transcription and phenotypic expression. In this study, we found that human chronic myeloid leukemia K562 cell-differentiated megakaryocytes and murine platelets produced bioactive substances and these are released into the extracellular space, partly in their exosomal form. Ca-A Cancer Journal For Clinicians Impact Factor, IF, number of article, detailed information and journal factor. Learn about publishing Open Access with us Journal metrics 1.760 (2019) Impact factor 1.902 (2019) Five year impact factor 34 days Submission to first decision 151 days Submission to acceptance 91,831 (2019) Downloads The statements, opinions and data contained in the journals are solely EPCs in cancer produce reactive oxygen species (ROS), transforming growth factor β (TGF-β), interleukin-10 (IL-10) and express programmed death-ligand 1 (PD-L1) and potently suppress T-cells. Quantitative assessment of FDG uptake can often be applied for treatment monitoring after chemotherapy. Therefore. Addendum: Cruz, B., et al. The suppressive effect of dipyridamole on cancer cell survival was paralleled by a reduction of HMGB1/receptor for advanced glycation end-products axis, and proliferation- and migration-related β-catenin, Yes-associated protein 1, Runt-related transcription factor 2, and TGF- β1/Smad signals. To routinely monitor cancer plasticity and guide treatment strategies, it is highly desired to provide information about metastatic status in real-time. CAR-T technology has achieved significant successes in treatment of certain cancers, primarily liquid cancers. The role of miR-21 in BrCa initiation was evaluated by implanting wild-type miR-21 BrCa cells into genetically engineered mouse models where miR-21 was intact, heterozygous or globally ablated. Journal. Finally, blocking TARC signaling and thus inhibiting pathological Th2 cell recruitment could be a therapeutic strategy in cHL. Therefore, the parental (=sensitive) and docetaxel (DX)-resistant PCa cell lines, PC3, DU145, LNCaP, and 22Rv1 were exposed to SHI [0.1–1.5 μM], and tumor cell growth, proliferation, cell cycling, cell death (apoptosis, necrosis, and necroptosis), and metabolic activity were evaluated. In this study, we found that human chronic myeloid leukemia K562 cell-differentiated megakaryocytes and murine platelets produced bioactive substances and these are released into the extracellular space, partly. Of these, 56 (80%) patients had human immunodeficiency virus (HIV) infection, eight were HIV-negative, and six had unknown HIV status. Journal information Editor-in-Chief. It plays an important role in T cell development, trafficking and activation of mature T cells after binding to its receptor C-C chemokine receptor type 4 (CCR4) and consecutive signal transducer and activator of transcription 6 (STAT6) activation. Search in: Advanced search. Subscribe to receive issue release notifications and newsletters from MDPI journals, You can make submissions to other journals. Impact Factor: 4.702 ℹ Impact Factor: 2019: 4.702 The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. Spheroids are of lower. Cancer Reports is a peer-reviewed, international, open access journal covering basic, translational, clinical and interdisciplinary cancer research.Read more here.. In addition, volumetric parameters such as metabolic tumour volume (MTV) have been introduced for quantitative assessment of FDG uptake in tumour. Finally a patient tissue microarray was used to interrogate connections between putative pathway components connecting JAM-A and HER3. Chimeric antigen receptor T cells (CAR-T) utilize T cell receptor (TCR) signaling cascades and the recognition functions of antibodies. Accumulation of F-18 fluorodeoxyglucose (FDG) may reflect tumour characteristics based on its metabolic activity. You seem to have javascript disabled. Oncogenic miR-21 is upregulated in many cancers, including BrCa, and is associated with poor survival and treatment resistance. This means that your research will feature in an issue quicker than ever before, as well benefiting from fast online publication through Early View, to ensure it is available to make the biggest impact, quickly. Techniques to develop three-dimensional cell culture models are rapidly expanding to bridge the gap between conventional cell culture and animal models. Please note that many of the page functionalities won't work as expected without javascript enabled. The lymphoma cells showed plasmablastic, immunoblastic, or anaplastic morphology. The authors wish to add the following statement in the Acknowledgements section of this paper [...], Ewing’s Sarcoma (ES) is the second most frequent malignant bone tumour in children and young adults and currently only untargeted chemotherapeutic approaches and surgery are available as treatment, although clinical trials are on-going for recently developed ES-targeted therapies. During 2017, the Journal Citation Reports (JCR) database tracked all impact factors for 12,298 journals. PDX-Derived Ewing’s Sarcoma Cells Retain High Viability and Disease Phenotype in Alginate Encapsulated Spheroid Cultures, Three-Dimensional Culture Systems in Cancer Research, Primary Effusion Lymphoma: A Clinicopathological Study of 70 Cases, Exosomal HMGB1 Promoted Cancer Malignancy, Chemical Modulation and Analytical Detection of Cancer Stem Cells, Circulating Tumour Cells, and Other Non-bulk Cancer Cell Types, Gastric Cancer Risk Prediction Using an Epidemiological Risk Assessment Model and Polygenic Risk Score, The Value of Real-World Data in Understanding Prostate Cancer Risk and Improving Clinical Care: Examples from Swedish Registries, Prostate Cancer—from Molecular Mechanisms to Clinical Care, Organoid and Spheroid Tumor Models: Techniques and Applications, Worm-Based Microfluidic Biosensor for Real-Time Assessment of the Metastatic Status, RNA-Seq Analysis Reveals CCR5 as a Key Target for CRISPR Gene Editing to Regulate In Vivo NK Cell Trafficking, Human Epidermal Growth Factor Receptor-3 Expression Is Regulated at Transcriptional Level in Breast Cancer Settings by Junctional Adhesion Molecule-A via a Pathway Involving Beta-Catenin and FOXA1, Molecular Mechanisms of Cancer Drug Resistance: Emerging Biomarkers and Promising Targets to Overcome Tumor Progression, Tumor Immune Evasion Induced by Dysregulation of Erythroid Progenitor Cells Development, Quantitative FDG PET Assessment for Oncology Therapy, PET and MRI Radiomics in Cancer Predictive Modeling, Complete Removal of the Lesion as A Guidance in the Management of Patients with Breast Ductal Carcinoma in Situ, Targeting CAR to the Peptide-MHC Complex Reveals Distinct Signaling Compared to That of TCR in a Jurkat T Cell Model, Challenges and Opportunities for Effective Cancer Immunotherapies, Clinical and Genetic Findings in Patients with Neurofibromatosis Type 1, Inhibition of HIFs as an Anti-Cancer Strategy, Drug Resistance and Novel Therapies in Cancers, Strategies for liver transplantation in liver cancers. As the flagship journal of the American Cancer Society, CA: A Cancer Journal for Clinicians reaches a diverse group of oncology specialists, primary care clinicians, and other professionals who interact with cancer patients. Guest Editors: Giulio Piluso, Claudia Santoro, Guest Editors: Leticia Oliveira-Ferrer, Volkmar Müller, Isabell Witzel, Guest Editors: George Simos, Ilias Mylonis, Georgia Chachami, Guest Editors: Michele Milella, Alessandro Antonelli, Matteo Brunelli, Help us to further improve by taking part in this short 5 minute survey, Irish Association for Cancer Research (IACR), miR-21 Plays A Dual Role in Tumor Formation and Cytotoxic Response in Breast Tumors, Unmet Medical Needs and Future Perspectives for Leiomyosarcoma Patients—A Position Paper from the National LeioMyoSarcoma Foundation (NLMSF) and Sarcoma Patients EuroNet (SPAEN), New Directions for Treating Soft Tissue Sarcomas, Biology and Clinical Applicability of Plasma Thymus and Activation-Regulated Chemokine (TARC) in Classical Hodgkin Lymphoma, B Cell Malignancies (including B Cell Lymphoma, Multiple Myeloma and B-CLL), Control of Cell Growth and Proliferation by the Tribbles Pseudokinase: Lessons from Drosophila, Pseudokinases, Tribbles Proteins and Cancer, Shikonin Reduces Growth of Docetaxel-Resistant Prostate Cancer Cells Mainly through Necroptosis, Recent Scientific Developments in Metastatic Prostate Cancer, Application of Multilayer Evidence for Annotation of C-Terminal, The Long Journey into BRCA1/2 Genes Goes On: The Emerging Landscape in BRCA-Mediated Tumors. The impact factor (IF) 2018 of CA - A Cancer Journal for Clinicians is 206.85, which is computed in 2019 as per it's definition.CA - A Cancer Journal for Clinicians IF is increased by a factor of 0.05 and approximate percentage change is 0.02% when compared to preceding year 2017, which shows a rising trend. Journal of Cancer Science & Therapy: Open Access Cancer is a pathological condition, where assemblage of cells displays uncontrolled growth, invasion and sometimes metastasis. Oncogenic miR-21 is upregulated in many cancers, including BrCa, and is associated with poor survival and treatment resistance. Impact Factor: 7.275 ℹ Impact Factor: 2019: 7.275 The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. Within this complex network of interactions, the establishment and maintenance of immune evasion mechanisms are crucial for cancer progression. Background: Metastasis is a complex process that affects patient treatment and survival.

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